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The diagnosis of the coronavirus disease 2019 (COVID-19) is normally achieved by either reverse-transcriptase polymerase chain reaction (RT-PCR) assay or lateral flow device testing. Many countries provide lateral flow devices to their citizens for free or subsidize the cost. Moreover, testing is required by several governments in order to travel internationally. However, this data only provides information on infection with severe acute respiratory syndrome coronavirus 2 [...]

Brazilian researchers who study a native venomous fish have confirmed a route to drug development for the treatment of chronic inflammatory diseases such as multiple sclerosis and asthma. The venomous toadfish Thalassophryne nattereri contains a peptide (TnP) with anti-inflammatory and anti-allergic potential. Confirmation of this potential has now come via the zebrafish Danio rerio, a popular aquarium species native to South Asia that shares 70% of its genome with humans and is widely used as [...]

Researchers affiliated with the Center for Cell-Based Therapy (CTC (ctcusp.org/rationale-2/presentation)) in Ribeirão Preto, Brazil, have identified for the first time a non-hereditary mutation in blood cells from a patient with GATA2 deficiency, a rare autosomal disease caused by inherited mutations in the gene that encodes GATA-binding protein 2 (GATA2). GATA2 regulates the expression of many genes that play a key role in developmental processes and cell renewal. The researchers [...]

Two independent clinical studies—one by researchers at the Center for Cell-Based Therapy (CTC) in Ribeirão Preto, state of São Paulo (Brazil), on the monoclonal antibody eculizumab, and the other by scientists at the University of Pennsylvania in Philadelphia (U.S.) on an experimental drug called AMY-101—observed a significant anti-inflammatory effect that contributed to a faster recovery by severe COVID-19 patients. The results of the two studies, which set out to [...]

Overweight and obese adolescents have similar increased risks of developing heart disorders, say researchers. “Until recently, overweight in adolescence wasn’t considered as important a risk as obesity for the development of cardiovascular disease. We found the risks to be similar in both cases,” said study lead author Vitor Engracia Valenti, Professor at Sao Paulo State University in Brazil. The study involved a small group of adolescents, aged between 10 and 17. The [...]