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Drug Target Review (Reino Unido)
Em 2021: 0 notícias
Desde 1995: 7 notícias
Drug target to tackle COVID-19 inflammatory processes identified
Publicado em 02 dezembro 2020
Researchers have demonstrated that an immune mechanism known as the inflammasome participates in the activation of the inflammatory process that can damage several organs and even lead to death during infection from SARS-CoV-2 , the virus causing the COVID-19 pandemic. The study was conducted at the University of São Paulo (USP), Brazil.
According to the authors, the findings support the use of inflammasome activation as a marker of disease prognosis and as a potential therapeutic [...]
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Novel molecule effectively treats arthritis in mice, study shows
Publicado em 12 agosto 2020A molecule called TPPU has been shown to inhibit an enzyme that plays a key role in inflammation, successfully treating arthritis in mice. A new molecule developed in the laboratory has shown potential therapeutic effects to treat arthritis in mice. The research was conducted at the São Paulo Research Foundation (FAPESP), Brazil. Tested in mice with genetically induced arthritis, the researchers found their molecule suppressed the inflammatory process, reducing both inflammation and [...]ver notícia -
Experimental drug reduces zika virus replication and protects developing mouse pups
Publicado em 21 julho 2020The novel aryl hydrocarbon receptor (AHR) inhibiting drug slowed zika virus replication and prevented mouse foetuses malforming in infected mothers. Researchers have discovered that inhibiting the aryl hydrocarbon receptor (AHR), a protein with roles in regulating immunity, stem cell maintenance and cellular differentiation, enables the immune system to combat zika virus more effectively. The oral AHR inhibitor was able to prevent the development of microcephaly and other malformations in the [...]ver notícia -
Electric Eel Species With Most Powerful Shock Ever Discovered in Amazon
Publicado em 11 setembro 2019A new species of electric eel with the most powerful shock of any animal ever discovered has been found in the Amazon. The creature is one of three species now confirmed to exist. For the last 250 years, since electric eels were first identified, it was thought there was just one species in the genus. In a study published in Nature Communications, researchers led by C. David de Santana, from the Smithsonian's National Museum of Natural History, analyzed over 100 fish collected across [...]ver notícia -
Oral squamous cell carcinoma prognostic signature identified
Publicado em 06 dezembro 2018Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis…ver notícia -
Cannabidiol shows sustained effects against depression
Publicado em 03 setembro 2018Researchers have found that a single dose of cannabidiol in rats with symptoms of depression was highly effective at eliminating symptoms…ver notícia -
Key role of PI3Ky in Chagas disease described
Publicado em 16 julho 2018The expression of PI3Ky increases during infection by T.cruzi, providing an essential response controlling the parasite and avoiding inflammation…ver notícia