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For the first time, researchers have tested a molecule that combines three distinct technologies against glioblastoma, the most aggressive type of brain cancer. A drug carrier that can reach the brain, bind to glioblastoma multiforme, and release a chemotherapeutic agent has been tested for the first time by researchers from São Paulo State University’s School of Pharmaceutical Sciences in Araraquara (FCFAr-UNESP), Brazil. The study, which was recently published in [...]

Scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development, and gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Numerous neurological and neuropsychiatric diseases, including autism spectrum disorders (ASD) and schizophrenia, have been linked to transcription factor 4 (TCF4) mutations, an essential gene in brain development. Transcription factors [...]

A new study has revealed a cannabidiol analogue can possibly prevent neuropathic pain induced by chemotherapy, as well as being beneficial against cancer. Researchers at the University of São Paulo’s Ribeirão Preto Medical School (FMRP-USP), Brazil found that a substance analogous to cannabidiol (CBD) could enhance chemotherapy by preventing neuropathic pain, but also could be beneficial against cancer. The study, published in Neurotherapeutics , showed that [...]

Researchers have demonstrated that an immune mechanism known as the inflammasome participates in the activation of the inflammatory process that can damage several organs and even lead to death during infection from SARS-CoV-2 , the virus causing the COVID-19 pandemic. The study was conducted at the University of São Paulo (USP), Brazil. According to the authors, the findings support the use of inflammasome activation as a marker of disease prognosis and as a potential therapeutic [...]

A molecule called TPPU has been shown to inhibit an enzyme that plays a key role in inflammation, successfully treating arthritis in mice. A new molecule developed in the laboratory has shown potential therapeutic effects to treat arthritis in mice. The research was conducted at the São Paulo Research Foundation (FAPESP), Brazil. Tested in mice with genetically induced arthritis, the researchers found their molecule suppressed the inflammatory process, reducing both inflammation and [...]

The novel aryl hydrocarbon receptor (AHR) inhibiting drug slowed zika virus replication and prevented mouse foetuses malforming in infected mothers. Researchers have discovered that inhibiting the aryl hydrocarbon receptor (AHR), a protein with roles in regulating immunity, stem cell maintenance and cellular differentiation, enables the immune system to combat zika virus more effectively. The oral AHR inhibitor was able to prevent the development of microcephaly and other malformations in the [...]

A new species of electric eel with the most powerful shock of any animal ever discovered has been found in the Amazon. The creature is one of three species now confirmed to exist. For the last 250 years, since electric eels were first identified, it was thought there was just one species in the genus. In a study published in Nature Communications, researchers led by C. David de Santana, from the Smithsonian's National Museum of Natural History, analyzed over 100 fish collected across [...]

Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis…

Researchers have found that a single dose of cannabidiol in rats with symptoms of depression was highly effective at eliminating symptoms…