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Drug Target Review (Reino Unido)
Em 2022: 4 notícias
Desde 1995: 11 notícias
Study reveals potential therapeutic targets for pancreatic cancer
Publicado em 28 julho 2022
Researchers analysed the expression of long non-coding RNAs in samples from patients and tumour cell lines, identifying a group of genes with augmented expression in pancreatic cancer.
According to a new study supported by the São Paulo Research Foundation (FAPESP), Brazil, long non-coding RNAs (IncRNAs) appear to play a role in pancreatic cancer. The researchers analysed a set of lncRNAs in pancreatic tumour cell lines, using specific tools in the laboratory to manipulate [...]
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A combination of nanotechnology, chemotherapy and a monoclonal antibody could treat glioblastoma
Publicado em 30 junho 2022For the first time, researchers have tested a molecule that combines three distinct technologies against glioblastoma, the most aggressive type of brain cancer. A drug carrier that can reach the brain, bind to glioblastoma multiforme, and release a chemotherapeutic agent has been tested for the first time by researchers from São Paulo State University’s School of Pharmaceutical Sciences in Araraquara (FCFAr-UNESP), Brazil. The study, which was recently published in [...]ver notícia -
Researchers use brain organoids to identify neural abnormalities and test gene therapy tools
Publicado em 04 maio 2022Scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development, and gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Numerous neurological and neuropsychiatric diseases, including autism spectrum disorders (ASD) and schizophrenia, have been linked to transcription factor 4 (TCF4) mutations, an essential gene in brain development. Transcription factors [...]ver notícia -
Cannabidiol analogue could enhance chemotherapy by preventing neuropathic pain
Publicado em 01 março 2022A new study has revealed a cannabidiol analogue can possibly prevent neuropathic pain induced by chemotherapy, as well as being beneficial against cancer. Researchers at the University of São Paulo’s Ribeirão Preto Medical School (FMRP-USP), Brazil found that a substance analogous to cannabidiol (CBD) could enhance chemotherapy by preventing neuropathic pain, but also could be beneficial against cancer. The study, published in Neurotherapeutics , showed that [...]ver notícia -
Drug target to tackle COVID-19 inflammatory processes identified
Publicado em 02 dezembro 2020Researchers have demonstrated that an immune mechanism known as the inflammasome participates in the activation of the inflammatory process that can damage several organs and even lead to death during infection from SARS-CoV-2 , the virus causing the COVID-19 pandemic. The study was conducted at the University of São Paulo (USP), Brazil. According to the authors, the findings support the use of inflammasome activation as a marker of disease prognosis and as a potential therapeutic [...]ver notícia -
Novel molecule effectively treats arthritis in mice, study shows
Publicado em 12 agosto 2020A molecule called TPPU has been shown to inhibit an enzyme that plays a key role in inflammation, successfully treating arthritis in mice. A new molecule developed in the laboratory has shown potential therapeutic effects to treat arthritis in mice. The research was conducted at the São Paulo Research Foundation (FAPESP), Brazil. Tested in mice with genetically induced arthritis, the researchers found their molecule suppressed the inflammatory process, reducing both inflammation and [...]ver notícia -
Experimental drug reduces zika virus replication and protects developing mouse pups
Publicado em 21 julho 2020The novel aryl hydrocarbon receptor (AHR) inhibiting drug slowed zika virus replication and prevented mouse foetuses malforming in infected mothers. Researchers have discovered that inhibiting the aryl hydrocarbon receptor (AHR), a protein with roles in regulating immunity, stem cell maintenance and cellular differentiation, enables the immune system to combat zika virus more effectively. The oral AHR inhibitor was able to prevent the development of microcephaly and other malformations in the [...]ver notícia -
Electric Eel Species With Most Powerful Shock Ever Discovered in Amazon
Publicado em 11 setembro 2019A new species of electric eel with the most powerful shock of any animal ever discovered has been found in the Amazon. The creature is one of three species now confirmed to exist. For the last 250 years, since electric eels were first identified, it was thought there was just one species in the genus. In a study published in Nature Communications, researchers led by C. David de Santana, from the Smithsonian's National Museum of Natural History, analyzed over 100 fish collected across [...]ver notícia -
Oral squamous cell carcinoma prognostic signature identified
Publicado em 06 dezembro 2018Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis…ver notícia -
Cannabidiol shows sustained effects against depression
Publicado em 03 setembro 2018Researchers have found that a single dose of cannabidiol in rats with symptoms of depression was highly effective at eliminating symptoms…ver notícia