To check the speculation of salivary glands being a room for coronavirus replication, the researchers analyzed the salivary glands of 24 sufferers who died from COVID-19 via ultrasound-guided autopsies. The tissue samples extracted from these glands underwent an RT-PCR take a look at which revealed the presence of virus in additional than two-thirds of the samples. Immunostaining procedures additionally revealed the presence of viruses within the tissue samples.
‘Electron microscopic visualization of salivary gland tissues revealed that the novel coronavirus could replicate in the cells that make up those glands.’
When the researchers examined the samples beneath an electron microscope, they discovered that SARS-CoV-2 might additionally multiplicate in these tissues.
“We’re going to partner with researchers at the University of North Carolina in the United States to map the distribution of these receptors in the mouth and quantify viral replication in oral tissues,” stated Luiz Fernando Ferraz da Silva, stated principal investigator of the examine.
It is very important notice that the identical analysis workforce demonstrated the traces of the novel coronavirus RNA within the tissues that encompass tooth. The present examine obtained assist from the Sao Paulo analysis basis, and findings have been revealed within the Journal of Pathology.
“This is the first report of a respiratory virus’s capacity to infect and replicate in salivary glands. Until now, it was thought that only viruses that cause highly prevalent diseases such as herpes used salivary glands as reservoirs. The discovery may help explain why SARS-CoV-2 is so infectious,” highlighted Bruno Fernandes Matuck, a Ph.D. candidate at USP’s Dental Faculty and first creator of the article.