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Researchers at Brazil’s University of Sao Paulo have discovered mechanisms involved in dental pulp inflammation and root apex damage. Such findings may be key in developing therapeutic approaches to mitigate damage such as bone loss resulting from endodontic infection. 1 In conducting two studies on mice, the researchers focused on a key mechanism element, a tumor necrosis factor-a receptor (TNFR1), which becomes pro-inflammatory when binding to the cytokine TNF-a. They found that in [...]