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Fungi and bacteria can activate genes associated with head and neck tumors, according to an in vitro study at São Paulo State University (UNESP) in Araraquara, Brazil. The metabolism of biofilms stimulates tumor cells by favoring the cell signaling pathways required for tumor development and resistance to treatment, the UNESP researchers said. These findings include entirely novel information about the links between microbial biofilms and cell behavior in head and neck cancer, said the [...]

Adults with periodontitis transmit bacteria that can cause the disease in the future to their children, and the bacteria remain in the oral cavity even when the children undergo various kinds of treatment, reinforcing the need for preventive care in the first year of a baby’s life, according to researchers at the University of Campinas (UNICAMP) in Brazil.  The parents’ oral microbiome is a determinant of the subgingival microbial colonization of their children, the [...]

Maresin and resolvin, produced by the body from omega-3 fatty acids, can help repair tissue damaged by periodontal disease, according to the University of São Paulo’s dental school (FO-USP) in Brazil and the Forsyth Institute in the United States. Even in the presence of inflammation, the researchers said, these molecules can stimulate periodontal ligament cells. The periodontal ligament is one of the structures lost in severe cases of the disease. Also, local [...]

The goal of the study was to identify reliable biomarkers in saliva that correlated with those found in the blood as a contribution to the development of quick tests to monitor health, especially in children. “The idea is to enable saliva to be more widely used as an alternative biological sample for clinical analysis. The advantage of saliva is that it can be collected several times noninvasively and painlessly, like urine,” said Paula Midori Castelo, a professor at UNIFESP and [...]

Researchers in Brazil have identified a correlation between oral cancer progression and the abundance of certain proteins present in tumor tissue and saliva. The discovery offers a parameter for predicting progression of the disease—whether cervical lymph node metastasis is present, for example—and points to a strategy for overcoming the limitations of clinical and imaging exams, the researchers note, adding that it also could help guide the choice of an ideal treatment for each [...]