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Covid may lead to emergence of ‘superfungus’ in Brazil, say scientists

Publicado em 15 junho 2021

Overcrowded hospitals, exhausted health care workers, and other factors are creating “ideal conditions” for the emergence of a “superfungus” with the ability to resist drug treatment, warn scientists.

The first two cases of infection with the fungus Candida auris in Covid patients, described in the Journal of Fungi, was reported in a hospital in Salvador in the state of Bahia, Brazil.

“Nine other C auris patients have since been diagnosed at the same hospital, some colonised [with the fungus in their organism but not doing harm] and others infected,” study co-author Arnaldo Colombo from the Federal University of Sao Paulo said in a statement.

While no other cases have been reported in Brazil since, the researchers say there are grounds for concern.

“We’re monitoring the evolutionary characteristics of C auris isolates from patients at the hospital in Salvador, and we’ve already found samples with reduced sensitivity to fluconazole and echinocandins,” Mr Colombo said.

The latter, the scientists say, belong to the main class of drugs used to treat invasive candidiasis.

In some cases, they say the fungus enters the bloodstream and causes a systemic infection known as candidemia which is similar to bacterial sepsis.

Previous studies have reported that invasion of the bloodstream and the immune system’s exacerbated response to the pathogen can cause severe damage to several organs and even lead to death with mortality among candidemia patients reaching as high as 60 per cent.

“The species quickly becomes resistant to multiple drugs and isn’t very sensitive to the disinfectants used by hospitals and clinics,” Mr Colombo said.

“As a result, it’s able to persist in hospitals, where it colonises health workers and ends up infecting patients with severe Covid and other long-stay critical patients,” he added.

Scientists say the long hospital stays, urinary and central venous catheters, and steroids and antibiotics use on Covid patients disrupt their body’s beneficial bacteria and make them “ideal targets for C auris”.

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