Brazil: Pregnant women with COVID-19 disease are at a higher risk of developing pre-eclampsia, shows a recent review by Brazilian researchers. Pre-eclampsia is a pregnancy complication characterized by persistent high blood pressure, usually in the second half of pregnancy or shortly after delivery, and causes serious harm to the mother and baby. The study findings appear in the journal Clinical Science.
Infection by SARS-CoV-2 during pregnancy can reduce the availability of ACE2, a protein that plays an important part in placental development, control of blood pressure, and the circulatory adaptations required for fetal development.
The authors analyzed a large set of published data and concluded that the presence of SARS-CoV-2 in the maternal organism can cause alterations in levels of angiotensin-converting enzyme 2 (ACE2), the protein to which the virus binds in order to invade cells, and thereby impair the functioning of systems that depend on ACE2 to regulate blood pressure. Besides serving as a receptor for the virus, ACE2 plays a key role in establishing blood flow in the placenta and in the cardiovascular adaptations that occur during pregnancy.
"Based on the findings of studies conducted to date on infection by SARS-CoV-2 in pregnant women and the role of ACE2 in the placenta, it can be concluded that pregnant women run a higher risk of developing the severe form of COVID-19 than non-pregnant women. Mortality is higher among pregnant women with the disease, and Brazil has one of the world's highest rates of mortality from COVID-19 among pregnant women. Furthermore, pregnant women with the disease are more susceptible to pre-eclampsia and premature delivery," said Nayara Azinheira Nobrega Cruz, first author of the article. The study was part of her PhD research, conducted at the Federal University of São Paulo's Medical School (EPM-UNIFESP) with a scholarship from…
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COVID-19 during pregnancy tied to higher risk of pre-eclampsia: Study
Publicado em 27 agosto 2021
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