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Chemical probe can regulate signaling pathway and block cell invasion by arboviruses

Publicado em 15 março 2019

Researchers at the Center for Medicinal Chemistry (CQMED) have discovered a way to regulate this pathway. Created with support from São Paulo Research Foundation -- FAPESP through its Research Partnership for Technological Innovation program (PITE, CQMED is a unit of the Brazilian Agency for Industrial Research and Innovation (EMBRAPII) that specializes in biopharmaceuticals and pharmaceuticals, comprising researchers from the University of Campinas's Center for Molecular Biology and Genetic Engineering (CBMEG) and the same university's Biology Institute (IB-UNICAMP).

CQMED partners with the Structural Genomics Consortium (SGC) and is also supported through the National Institutes of Science and Technology (INCT) program by (FAPESP), the National Council for Scientific and Technological Development (CNPq) and Brazil's Coordination for the Improvement of Higher Education Personnel (CAPES).

Study - Collaboration - Laboratories - SGC - UNICAMP

The study was a collaboration between laboratories from the SGC at UNICAMP, the University of North Carolina at Chapel Hill (USA), the University of Oxford (UK), the Goethe University Frankfurt (Germany), and other research institutions located in the United States, United Kingdom and Japan. The results have been published in the journal Cell Reports.

"Using a chemically synthesized compound we've developed over the last few years, we were able to advance our understanding of the regulation of the beta-catenin-dependent Wnt signaling pathway," Roberta Regina Ruela de Souza told Agência FAPESP. A lead author of the study, Souza is a postdoctoral researcher at SGC-UNICAMP with a scholarship from FAPESP. The chemical compound used to study the functions of the Wnt signaling pathway was a selective inhibitor of AP2-associated kinase 1 (AAK1) and developed by researchers at SGC-UNICAMP.

Research - Involvement - AAK1 - Endocytosis - Process

Previous research has suggested the involvement of AAK1 in endocytosis, the process by which cells internalize substances from their external environment, such as micronutrients and even some viruses and bacteria. Endocytosis is known to play a role in regulating the Wnt signaling pathway, while inhibition of AAK1...

(Excerpt) Read more at: ScienceDaily