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A new strategy for preventing complications associated with sepsis is presented by researchers affiliated with the University of São Paulo (USP) and collaborators in an articlepublishedin the journalBlood. The proposal is to inhibit the action of a protein called gasdermin D, which the authors show is possible with disulfiram, a drug already approved for human use and originally indicated to combat alcohol dependence. The study was conducted at the Center for Research on [...]

In a study conducted at the University of São Paulo’s Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals’ survival rate. In a study conducted at the University of São Paulo’s Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of [...]

 It’s an everyday scene. Pooch wants a tasty-looking piece of cake that’s sitting on the table. What does he do? He gazes longingly at the titbit, ogles his master or mistress, and glances back at the cake. This “conversation” with humans gets him what he wants. Communication between dogs and humans involving an exchange of looks is very common, but different life experiences can change it, according to a study conducted at the University of São Paulo (USP) [...]

In COVID-19 patients, obesity is the factor most associated with the development of endothelial dysfunction, a condition in which the blood vessels become unable to contract and relax adequately, increasing the risk of events such as heart attacks, thrombosis (blood clotting), and stroke.  Endothelium refers to the thin sheet of cells lining the walls of arteries and veins, as well as the inside of the heart. Endothelial cells release substances that control vascular relaxation and [...]

By Karina Ninni | Agência FAPESP–Yellow fever is a non-contagious viral disease with two transmission cycles, sylvatic (in wild animals) and urban. Sylvatic yellow fever circulates among monkeys, and in Brazil is transmitted by mosquitoes of the generaHaemagogusandSabethes, which bite an infected monkey and then infect others. Urban yellow fever circulates among humans and is transmitted by the mosquitoAedes aegypti(human-mosquito-human). Brazil has had no urban yellow fever cases [...]

By Karina Toledo | Agência FAPESP–Torquetenovirus (TTV) is one of the viruses most frequently found in the human organism. It is also common in monkeys and domestic animals. Its presence has not been associated with any known disease, but its excessive replication is a sign that something is wrong with the immune system. The correlation between high TTV load and immunosuppression has been used in medicine in certain contexts, such as monitoring transplant patients who take [...]

A water-borne fungus that has led to the extinction of several species of amphibians that spend all or part of their life cycle in water is also threatening terrestrial amphibians. In Brazil, researchers supported by FAPESP detected unprecedented mortality among a genus of tiny frogs known as pumpkin toadlets that live in the Atlantic Rainforest far from any aquatic environments. The animals were severely infected by chytrid fungus (Batrachochytrium dendrobatidis), which causes [...]

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients. The study shows that interaction with angiotensin-converting enzyme 2 (ACE2) not only enables the virus to [...]

Gluten is a protein complex found in cereals such as wheat, rye and barley. It is responsible for the elastic texture of dough so that loaves and rolls can be baked into different shapes while remaining flexible and crusty. It also lengthens the shelf life of bread at room temperature, when associated with preservatives. Gluten intolerance, however, has become a global epidemic, and gluten-free products are increasingly popular. The problem is that most of those available on the market are far [...]