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A study reported in Proceedings of the National Academy of Sciences (PNAS) shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body's response to bacterial infection. We discovered that mice that don't produce this protein are more protected against intestinal infections by bacteria like Clostridioides difficile and Citrobacter rodentium." Marco Aurélio Ramirez Vinolo, co-author of the article He is a [...]

In a paper published in Psychiatry Research, Brazilian scientists described molecular alterations identified in the blood and brain tissue of individuals who died by suicide. The study aimed to uncover susceptibility factors and potential targets for innovative pharmacological interventions. Globally, over 700,000 people die by suicide annually, with a significant impact on the 15-29 age group where it ranks as the fourth leading cause of death. Risk factors for suicide encompass family [...]

Infection from SARs-CoV-2 often results in numerous neurological impacts, resulting in staple symptomology for COVID-19 like loss of smell (anosmia) and migraines. To uncover more about this virus’ mechanisms within the central nervous system, researchers have investigated how COVID-19 impacts brain cells. The Brazilian team has been investigating COVID-19’s role in the brain since 2020, when they released groundbreaking findings revealing that the virus causing COVID-19 infects [...]

In a study reported on Frontiers in Immunology, Brazilian researchers from Sao Paolo University have taken the first steps toward understanding why some people are naturally resistant to SARS-CoV-2 infection. The results suggest that certain genetic variants found more frequently in resistant subjects are associated with more efficient activation of natural killers (NKs). “Our hypothesis is that the genomic variants most frequently found in the susceptible spouse lead to the production [...]