55-70 yaşındaki kadınları içeren bir klinik araştırmaya göre, bu besinin diyete eklenmesi vücudun antioksidan savunmasını güçlendirebilir ve muhtemelen diyabet, yüksek tansiyon ve kardiyovasküler hastalık geliştirme şansını azaltabilir. Bununla birlikte, etkinliğini doğrulamak için daha fazla araştırmaya ihtiyaç vardır.
Çalışmaya göre, amino asit taurin, yaşlanma karşıtı tedavilerde kullanılabilir.
Hücrelerimiz, soluduğumuz oksijeni ve var olmak için her gün tükettiğimiz gıdayı parçaladıklarında “serbest radikaller” olarak bilinen potansiyel olarak toksik yan ürünler üretirler. Bu moleküllerin bazıları önemli biyolojik işlevleri yerine getirir, ancak bunların çok fazla olması halinde, iç hücre yapıları hasar görebilir, bu da hücrelerin işlev yeteneğini bozabilir ve muhtemelen kronik hastalığa neden olabilir. Bu sürece oksidatif stres diyoruz.
Vücudumuz, reaktif oksijen türlerinin sağlıklı dengesini korumaya yardımcı olan kayda değer bir antioksidan enzim cephaneliğine sahiptir, ancak yaşlandıkça bu kontrol mekanizmaları azalır. Dergide yayınlanan yeni bir araştırma Beslenme diyetinizi amino ile takviye etmenizi önerir.[{” attribute=””>acid taurine could be a realistic approach to address the issue.
The study reported in the study was carried out at the University of São Paulo (USP) in Brazil. It involved 24 female volunteers aged 55 to 70. They were randomly separated into two groups. One group consumed three 500 mg capsules of taurine per day for 16 weeks (1.5 g per day). The other group received pills that simply contained corn starch (placebo). Neither the volunteers nor the researchers were aware of which group each participant belonged to.
Oxidative stress markers were analyzed in blood samples taken before and after the intervention. One of the most intriguing findings was an almost 20% rise in levels of the antioxidant enzyme superoxide dismutase (SOD) in the taurine group, compared to a 3.5% drop in the control group. SOD, the scientists explain, protects cells from the harmful reactions of the superoxide radical.
“Preventing the buildup of free radicals that naturally occurs with aging probably prevents cardiovascular disease, diabetes, and high blood pressure, among other chronic conditions,” said Ellen de Freitas. Freitas is a professor at the Ribeirão Preto School of Physical Education and Sports (EEFERP-USP) and co-principal investigator for a project supported by FAPESP.
According to Freitas, very few studies of the effects of taurine in the context of aging can be found in the scientific literature. “This study was a first step, aimed at investigating the ideal dose and possible side effects, none of which was observed in any of the participants,” she said.
Anti-aging therapy
Taurine is a nutrient found in certain foods, such as fish, shellfish, chicken, turkey, and beef. Additionally, it is naturally produced in some tissues of the human body, particularly the liver, and is important to the functioning of the central nervous system, immunity, eyesight, and fertility.
The Freitas group has been studying taurine’s antioxidant and anti-inflammatory properties for at least 10 years, initially in high-performance athletes and later in obese people, with daily dosages ranging from 3 g to 6 g. “The results showed that oxidative stress in these individuals could be controlled when their diet was supplemented with this amino acid. We then decided to test the strategy in the context of aging. This was very novel, so we began with a very low safety dose,” Freitas said.
The initial plan was to look at the effects of taurine supplementation in conjunction with exercise training, as well as both treatments separately. Physical activity is thought to be one of the main ways to regulate levels of oxidizing substances and antioxidants in the body, and the proper amount is thought to enhance the benefits of taurine. However, because of the pandemic and the fact that the volunteers were in a high-risk group for
Two other markers of oxidative stress were analyzed besides SOD: the antioxidant enzyme glutathione reductase (GR), which decreased significantly in both groups, and malondialdehyde (MDA), which increased 23% in the control group and decreased 4% in the taurine supplementation group.
“These results were modest, but we believe a higher dose of taurine could produce stronger evidence for its benefits,” Freitas said.
For Gabriela Abud, the first author of the article and currently a Ph.D. candidate at the Ribeirão Preto Medical School (FMRP-USP), changes in the volunteers’ diet in the early months of the pandemic owing to lockdown may have affected the results of the biochemical analysis.
“In addition to markers of oxidative stress, we analyzed levels of minerals such as selenium, zinc, magnesium, and calcium, which are important to the functioning of these enzymes,” Abud explained. “Selenium, for example, is a co-factor for glutathione peroxidase [which indirectly helps eliminate hydrogen peroxide from the organism] ve her iki grupta da azaldı.”
Freitas için taurin takviyeleri sadece “kek üzerine krema”dır ve tek başına mucizeler yaratamaz. Dengeli bir diyet ve düzenli egzersiz ile sağlıklı bir yaşam tarzı, yaşlanma karşıtı etkinin ortaya çıkması için esastır” dedi.
Bir sonraki çalışmada, grup, kronik inflamasyon tarafından şiddetlendirilebilen kademeli bir kas kütlesi kaybı olan sarkopenili 60-75 yaş arası obez kadınları dahil etmeyi planlıyor. Freitas, “Bu insanlar akut komplikasyon geliştirme riskiyle karşı karşıya. Günde 3 g taurin takviyesi ile ilişkili fiziksel eğitim sunacağız ve bu müdahalelerden kaynaklanan olası değişiklikleri gözlemleyeceğiz” dedi.
Taurin takviyesinin yararları ve risklerinin hala araştırıldığını akılda tutmak önemlidir. Diyet takviyeleri tıbbi gözetim olmadan alınmamalıdır.
Referans: “Olası Yaşlanma Karşıtı Tedavi Olarak Taurin: 55-70 Yaş Arasındaki Kadınlarda Taurin Antioksidan Aktivitesinin Kontrollü Bir Klinik Denemesi” Gabriela Ferreira Abud M.Sc., Flavia Giolo De Carvalho Ph.D., Gabriela Batitucci Ph.D., Sofia Germano Travieso B.Sc., Carlos Roberto Bueno Junior Ph.D., Fernando Barbosa Junior Ph.D., Julio Sergio Marchini Ph.D. ve Ellen Cristinide Freitas Ph.D., 11 Haziran 2022, Beslenme.
DOI: 10.1016/j.nut.2022.111706