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Em 2022: 0 notícias
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Arsenal used by parasite to affect cellular defense and enhance leishmaniasis is revealed
Publicado em 24 março 2021
Researchers have succeeded in revealing the arsenal used by protozoans of the genus Leishmania in human cells to make leishmaniasis more severe, especially in cases of the mucocutaneous variety of the disease, which can cause deformations in patients. The discovery points the way to a search for novel treatments for the disease as well as casting light on a key mechanism involved in other diseases.
The mechanism involves Leishmania, macrophages and a virus that lives endosymbiotically in the [...]
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Study finds inflammatory mechanism responsible for bone erosion in rheumatoid arthritis
Publicado em 18 março 2021In a study aimed at investigating the mechanism responsible for exacerbating rheumatoid arthritis in smokers, researchers at the Center for Research on Inflammatory Diseases (CRID), linked to the University of São Paulo (USP) in Brazil, discovered a novel path in the inflammatory process associated with the bone damage caused by rheumatoid arthritis. The discovery opens up opportunities for new therapeutic interventions to mitigate the effects of the disease, for which there is no [...]ver notícia -
Study reveals structure of protein and permits search for drugs against neglected diseases
Publicado em 08 janeiro 2021Brazilian researchers have managed to decipher the structure of a protein found in parasites that cause neglected tropical diseases, paving the way to the development of novel medications. Thanks to the discovery it will be possible to seek more potent molecules capable of destroying the pathogens directly, with fewer adverse side-effects for patients. The study detailed the structural characteristics of the protein deoxyhypusine synthase (DHS), found in Brugia malayi, one of the [...]ver notícia