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An article published in Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of defense cells that persist even after the patient is discharged from hospital. This cellular reprogramming creates a disorder the authors call post-sepsis syndrome, whose symptoms include frequent reinfections, cardiovascular alterations, cognitive disabilities, declining physical functions, and poor quality of life. The phenomenon explains why so many patients who survive sepsis [...]

Scientists affiliated with the Center for Research on Inflammatory Diseases (CRID), hosted by the University of São Paulo (USP) in Brazil, have discovered that an enzyme involved in key metabolic processes also plays a role in immune cell differentiation and hence in the development of autoimmune diseases. The finding could contribute to the future development of new treatments and more cost-effective and resolutive medications for this kind of disease. The study is reported in the [...]

Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry. In the study, which was supported by São Paulo Research Foundation—FAPESP, Brazilian researchers correlated information on genes associated with psychiatric and neurological disorders and drugs approved for use in treating other diseases that might potentially inhibit or activate these genes. The study identified 63 drugs [...]