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Kala-azar or visceral leishmaniasis, a deadly neglected tropical disease, can be better treated using a compound derived from Nectandra leucantha, a tree native to southern Brazil (local names: canela-seca or canela-branca), claimed a study. Kala-azar is caused by a protozoan parasite transmitted by a sand-fly bite and is characterised by long bouts of fever, loss of weight and muscle strength, enlargement of the spleen and liver, and anaemia. An international team of researchers from [...]

A novel treatment strategy involving a combination of two drugs has shown promising results in suppressing tumours by an unconventional method. The new approach, detailed in the journal Cancer Discovery, includes LB-100, currently in clinical trials for lung tumours, and WEE1 inhibitors, which prevent tumour DNA repair. The drug combo works by hyperactivating cancer cells to induce stress, making them more susceptible to targeted attack. The study reveals that the treatment's [...]

Despite its antioxidant effects and role in regulating sleep cycles, melatonin, popularly known as the “sleep hormone”, can worsen inflammation of the intestine and impair the action of gut microbiota, warned a study. Melatonin is often taken as a so-called food supplement without a doctor’s prescription by people with sleep problems. “It’s generally thought to be harmless. After all, it’s a hormone and can help regulate sleep. However, our study shows [...]

A review of the scientific literature published by Brazilian researchers shows that pregnant women infected by the novel coronavirus run a higher risk of developing pre-eclampsia, a pregnancy complication characterized by persistent high blood pressure, usually in the second half of pregnancy or shortly after delivery. The disorder can cause serious harm to mother and baby. An article with the findings of the review is published in the journal Clinical Science. The authors analyzed a [...]

Brazilian researchers have found that tissues which specialise in saliva production and secretion can serve as reservoirs for SARS-CoV-2, the virus causing COVID-19, magnifying its infectious potential. Researchers at the University of Sao Paulo (USP) analysed samples from three types of salivary gland obtained during a minimally invasive autopsy procedure performed on 24 patients who died from complications of COVID-19 and discovered that SARS-CoV-2 infects and replicates in the salivary [...]

Scientists now report that a high dose of vitamin D administered on admission to hospital has failed to improve the condition of patients with moderate or severe Covid-19. A clinical trial was conducted in Brazil with 240 patients who were given 200,000 IU of vitamin D3 on admission to hospital. The supplementation did not reduce length of stay or affect the proportion requiring intensive, according to the study published in the Journal of the American Medical Association (JAMA). In vitro [...]