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Study proves that antivenom reduces risk of skin necrosis in patients bitten by brown recluse spider
Publicado em 12 de janeiro de 2023
One of the most dreaded effects of the bite of the brown recluse spider (Loxosceles spp) is the appearance of a necrotic skin lesion, but a clinical study by Brazilian researchers recently reported in PLOS Neglected Tropical Diseases shows that the problem can be solved by administering antivenom, especially if this is done within 48 hours of the incident.
An antivenom produced by Butantan Institute, an arm of the São Paulo State Department of Health, was used in the study. As the [...]
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Bioactive compounds in a marine sponge show potential to kill antibiotic-resistant bacteria
Publicado em 13 julho 2022A research group led by scientists at the University of São Paulo (USP) in São Carlos, Brazil, has identified a number of bioactive compounds in a marine sponge collected on Fernando de Noronha, an archipelago about 400 km off the coast of Brazil's Northeast region. Some of the substances proved capable of killing bacteria that are resistant to currently available antibiotics, paving the way to development of new drugs. The study was supported by FAPESP and reported in an [...]ver notícia -
Older people with abdominal fat and weak muscles are more likely to develop mobility problems
Publicado em 01 setembro 2021Weak muscles and abdominal fat are a dangerous combination for older people who have difficulty walking. A study conducted by researchers at the Federal University of São Carlos (UFSCar) in the state of São Paulo, Brazil, in partnership with colleagues at University College London (UCL) in the UK, points to a significant loss of gait speed in older people with these two physical traits. A slower gait is a natural outcome of the aging process, but mobility problems can result if [...]ver notícia -
Study sheds light on immune mechanism that triggers cytokine storm typical of COVID-19
Publicado em 01 dezembro 2020Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death. An article reporting the findings of the study, which was supported by FAPESP, has just been published in the Journal of Experimental Medicine. According to the authors, the findings support the use of [...]ver notícia -
New strategy for treating the most aggressive type of brain cancer
Publicado em 27 novembro 2019Researchers from the University of São Paulo (USP) in Brazil have developed a strategy for treating the most aggressive type of brain cancer in adults that combines a photoactive molecule and a chemotherapeutic agent—both encapsulated in protein-lipid nanoparticles. Results of the research, supported by São Paulo Research Foundation—FAPESP, were presented during the FAPESP Week France symposium, by Antônio Claudio Tedesco, of the Center for Nanotechnology, [...]ver notícia -
Acute chikungunya infection studied at the molecular level in Brazilian patients
Publicado em 18 setembro 2019Computational tools applied to biology are revolutionizing the study of what happens inside cells during an infection, helping scientists to understand disease mechanisms and contributing to the identification of potential therapeutic targets. An example is a study published in PLOS Pathogens describing how Brazilian researchers analyzed blood cells from patients infected with chikungunya virus. With the aid of techniques such as complex network analysis, artificial intelligence and machine [...]ver notícia -
In test with rats, cannabidiol showed sustained effects against depression for seven days
Publicado em 31 agosto 2019Commercial antidepressants typically take two to four weeks to have a significant effect on a depressed patient. They are also ineffective in approximately 40 percent of cases. Finding new, fast-acting drugs for depression with longer-lasting effects is the goal of research conducted by Brazilian scientists in São Paulo State in collaboration with Danish colleagues. Their study found that a single dose of cannabidiol in rats with symptoms of depression was highly effective, eliminating [...]ver notícia -
Physical activity in adolescence and later life reduces the risk of colorectal adenoma
Publicado em 20 agosto 2019The effects of more than 60 minutes of moderate daily physical exercise, such as walking, accumulate throughout life and are associated with a 39% reduction in the risk of advanced adenomatous polyps, a precursor of colorectal cancer, the third most frequent type of cancer in Brazil. This is the main finding of an epidemiological study published in the British Journal of Cancer. The study was conducted by researchers in the Department of Preventive Medicine at the University of [...]ver notícia -
Sickle cell disease needs more attention
Publicado em 13 junho 2019The promise of new treatments for sickle cell disease, a group of inherited red blood cell disorders, has never been so great, but it will only be realized if there is constant investment in health policies such as programs for screening newborns, especially in sub-Saharan Africa, where most cases occur. This point is made in a comprehensive review of the main research findings regarding sickle disease published in Nature Reviews Disease Primers and signed by experts affiliated with [...]ver notícia