After the US transplanted a pig kidney to a brain-dead patient, USP should start testing

Publicado em 26 outubro 2021

After being carried out for the first time in the world, the transplantation of the kidney from a pig to a human in the United States of America (USA, the University of São Paulo (USP), with a similar line of research, started tests in this direction. research led by Silvano Raia, is a pioneer in liver transplantation in Latin America.The surgeon hopes that the first tests with human beings in Brazil will take place in two years, if the study gets investment to build a biosafety breeding (pig facility).

In an interview with Correio Braziliense, the researcher said that work in the US opens the door. “As much as the laboratory data indicated that we were on the right path, there were skeptics. The fact that they succeeded demonstrates that this line of research is promising,” he said. For geneticist Mayana Zatz, also involved in the research, the American success facilitates the approval of experiments by Brazilian ethics committees. “It’s important in the sense of showing: ‘Look, it’s already being done in the US,'” he said.

Also according to Coreio Braziliense, the Brazilian study was conceived by the researcher four years ago. The initiative was supported by the Foundation for Research Support of the State of São Paulo (Fapesp) and the pharmaceutical company EMS. The genetic engineering part, according to the scientists, consists of inactivating pig genes and adding human genes, performed with the CRISPR/Cas9 technique (in the method, Cas9, an enzyme in the bacterial defense system, together with an RNA , used as a guide, cuts the stretch of interest from a DNA). With this, it was possible to create genetically modified embryos, which need to be introduced into a matrix and created in the Pig Facility.

The researcher revealed that the first offspring will be generated in a common vivarium. From then on, pre-clinical tests will be performed in isolated perfusion, a system that allows the preservation of organs from donor collection to transplantation. The so-called preservation liquid (perfusate) is usually used. The experiment will, however, use human blood as a perfusate. “If the perfusion of the genetically modified kidney with human blood, for 12 hours, does not demonstrate rejection in both organ and perfusate biopsies, it will be demonstrated that our product is suitable to be transplanted in patients”, he said.


Essa notícia também repercutiu nos veículos:
Portal R7 Estadã Diário do Grande ABC online IstoÉ Dinheiro online BOL UOL Estado de Minas online SBT Interior IstoÉ online Estado de Minas online Correio Braziliense online O Estado de S. Paulo Jornal de Piracicaba Valter Vieira Blog Juraci Rebouças BN - Bahia Notícias BN - Bahia Notícias Blog do Fumanchú Notícias ao Minuto (Brasil) ClickCampos Roberto Crispim Band FM Tangará da Serra 92.1 Repórter Diário Clube FM 100.5 Melody FM 94.1 Caderno B Play Crazy Game Bem Paraná online Grande Picos Simões Online A Crítica (MS) online ES Brasil online Brasil 247 O Liberal (Americana, SP) online Marília Notícia Guarulhosweb Tribuna do Sertão Correio Popular (Campinas, SP) online Tribuna do Agreste TN Online A Crítica (MS) online Fato Amazônico Portal GMC Online FasterNet Folha Vitória online A Tribuna (Santos, SP) online Terra SCNotícias-BA Dom Total Portal Gongogi Notícias no Ar Farol da Bahia Revista Comunhão online ID News Altair Tavares Ganduzão Site Tribuna Portal Alô News Central das Notícias O Primeiro Portal Livre Notícias Índices Bovespa Altair Tavares Calila Notícias ES360 Jornal Cotia Agora Olhar Digital (Finlândia) Blog Itarantim Agora A Notícia Aqui Portal Itaparica Blog do Léo Santos Notícias do Dia Portal Ferraz e o Povo Tabocas Notícias Notícia da Bahia Na Hora Online Gazeta de S. Paulo online Muita Informação Rádio SAT Peruíbe SP 106.7 FM (Ribeirão Preto, SP) Pequi FM 87,5 Rádio Nova Aliança FM 105,9 Rádio Cultura FM 101,7 Rádio Nova Onda FM 87,9 Rádio Cidade Nova FM 104,9 Folha de Valinhos online InfoNavWeb Rádio Liberdade FM 87,9 Imbaú FM 87,9 Itaporã Agora Rádio Cultura FM Castelo 101,7 RR Mais Augusto Urgente - Jaco & Bina Portal Vilson Nunes Wiy Solutions Blog da Biblioteca da Escola de Engenharia e do Instituto de Computação Jornal Vale dos Sinos Jornal NH online Diário de Cachoeirinha online Diário de Canoas online Jornal de Gramado online Correio de Gravataí online Cidades em Foco Cidade Verde Terra