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Researchers at the University of São Paulo (USP) in Brazil have identified a new class of molecules capable of stopping the excessive inflammation typical of the severe form of COVID-19 without impairing the immune response to SARS-CoV-2, the virus that causes the disease.   The researchers conducted experiments with mice showing that the inflammation triggered by the cytokine storm was reduced when they blocked the link between a peptide called C5a and its cellular receptor, [...]

In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of the intestinal tract of chickens by these pathogenic bacteria and find better ways to combat the infection they cause. An article on the study is published in the journal Scientific Reports. In it, the researchers note that, contrary to expectations, the mutant strains caused more severe infections than wild-type bacteria. In the mutant strains, [...]

Women’s artistic gymnastics has attracted considerable attention at recent editions of the Olympic Games, thrilling huge crowds of spectators at the venue itself and gripping billions of viewers on TVs around the world. Murky and even unethical behavior may lie hidden behind these displays of beauty, grace and skill, however. Many countries subject their gymnasts to training regimes that involve sacrifices not seen by the fans or the media. In the unremitting pursuit of perfection [...]

The process of cellular aging is multifactorial, and its investigation involves several knowledge areas. Finding ways to protect cells against damage is a key focus. A group of researchers recently achieved noteworthy progress in this regard, as evidenced by an article published in Scientific Reports. According to the authors, in their study, the protein klotho protected glial cells against inflammation and death. Glia are non-neuronal cells of the brain and nervous system. There are several [...]

A qualitative study conducted by researchers at the University of São Paulo’s School of Arts, Sciences and Humanities (EACH-USP) in Brazil suggests that gender influences how people suffering from alcohol use disorder cope with their condition.  The principal investigator was Professor Edemilson de Campos, who was supported by FAPESP and collaborated with Nadia Narchi, also a professor at EACH-USP. The results are reported in an [...]

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients. The study shows that interaction with angiotensin-converting enzyme 2 (ACE2) not only enables the virus to [...]

Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent. Reports of MIS-C have been increasingly associated with severe cases and deaths in several countries including Brazil since the onset of the pandemic. Researchers [...]

The efficacy of biosensors used in clinical tests depends critically on the surface of the device on which the biorecognition molecules are immobilized. This surface can be adjusted and sometimes controlled using self-assembled molecular monolayers as matrices. The monolayers are films made up of organic molecules that under the right conditions assemble spontaneously on metal surfaces via chemical bonds between the sulfur atoms and the metal. A study conducted at the University of [...]

Brazilian researchers who study a native venomous fish have confirmed a route to drug development for the treatment of chronic inflammatory diseases such as multiple sclerosis and asthma. The venomous toadfish Thalassophryne nattereri contains a peptide (TnP) with anti-inflammatory and anti-allergic potential. Confirmation of this potential has now come via the zebrafish Danio rerio, a popular aquarium species native to South Asia that shares 70% of its genome with humans and is widely used as [...]