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Multiple sclerosis: How a probiotic could help with MS treatment
Publicado em 11 de agosto de 2023
Researchers say they are learning more about how gut bacteria can be used to treat autoimmune diseases.
In a study involving mice, researchers say they have developed a probiotic that could be a treatment for multiple sclerosis.
Experts say the probiotic would work in the same general way as diets do to control inflammation but may have longer-lasting effects.
Gut bacteria have been shown to be vitally important to overall health.
Now, a new study reports that these microbes also [...]
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Compound reduces inflammation in COVID-19-infected mice without compromising immune response to virus
Publicado em 25 julho 2023Researchers at the University of São Paulo (USP) in Brazil have identified a new class of molecules capable of stopping the excessive inflammation typical of the severe form of COVID-19 without impairing the immune response to SARS-CoV-2, the virus that causes the disease. The researchers conducted experiments with mice showing that the inflammation triggered by the cytokine storm was reduced when they blocked the link between a peptide called C5a and its cellular receptor, [...]ver notícia -
Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens
Publicado em 11 abril 2023In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of the intestinal tract of chickens by these pathogenic bacteria and find better ways to combat the infection they cause. An article on the study is published in the journal Scientific Reports. In it, the researchers note that, contrary to expectations, the mutant strains caused more severe infections than wild-type bacteria. In the mutant strains, [...]ver notícia -
Repressive methods used in training women’s artistic gymnasts can be extremely harmful, study warns
Publicado em 02 fevereiro 2023Women’s artistic gymnastics has attracted considerable attention at recent editions of the Olympic Games, thrilling huge crowds of spectators at the venue itself and gripping billions of viewers on TVs around the world. Murky and even unethical behavior may lie hidden behind these displays of beauty, grace and skill, however. Many countries subject their gymnasts to training regimes that involve sacrifices not seen by the fans or the media. In the unremitting pursuit of perfection [...]ver notícia -
Protein With Anti-Aging Action Combats Inflammation and Avoids Death of Neurons
Publicado em 01 fevereiro 2023The process of cellular aging is multifactorial, and its investigation involves several knowledge areas. Finding ways to protect cells against damage is a key focus. A group of researchers recently achieved noteworthy progress in this regard, as evidenced by an article published in Scientific Reports. According to the authors, in their study, the protein klotho protected glial cells against inflammation and death. Glia are non-neuronal cells of the brain and nervous system. There are several [...]ver notícia -
Gender may influence the way people cope with alcohol dependence
Publicado em 04 abril 2022A qualitative study conducted by researchers at the University of São Paulo’s School of Arts, Sciences and Humanities (EACH-USP) in Brazil suggests that gender influences how people suffering from alcohol use disorder cope with their condition. The principal investigator was Professor Edemilson de Campos, who was supported by FAPESP and collaborated with Nadia Narchi, also a professor at EACH-USP. The results are reported in an [...]ver notícia -
Study investigates the mechanism underlying kidney damage in COVID-19 patients
Publicado em 30 setembro 2021A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients. The study shows that interaction with angiotensin-converting enzyme 2 (ACE2) not only enables the virus to [...]ver notícia -
Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients
Publicado em 02 junho 2021Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent. Reports of MIS-C have been increasingly associated with severe cases and deaths in several countries including Brazil since the onset of the pandemic. Researchers [...]ver notícia -
Study could help develop biosensors for non-invasive diagnosis of diseases
Publicado emThe efficacy of biosensors used in clinical tests depends critically on the surface of the device on which the biorecognition molecules are immobilized. This surface can be adjusted and sometimes controlled using self-assembled molecular monolayers as matrices. The monolayers are films made up of organic molecules that under the right conditions assemble spontaneously on metal surfaces via chemical bonds between the sulfur atoms and the metal. A study conducted at the University of [...]ver notícia -
Molecule with potential to treat multiple sclerosis passes toxicology testing in zebrafish
Publicado emBrazilian researchers who study a native venomous fish have confirmed a route to drug development for the treatment of chronic inflammatory diseases such as multiple sclerosis and asthma. The venomous toadfish Thalassophryne nattereri contains a peptide (TnP) with anti-inflammatory and anti-allergic potential. Confirmation of this potential has now come via the zebrafish Danio rerio, a popular aquarium species native to South Asia that shares 70% of its genome with humans and is widely used as [...]ver notícia